Animal Models of Schizophrenia?
Professor David Lewis explains that although many symptoms of schizophrenia are not reproducible in animals, animal models can help understand the disorder.
The study of schizophrenia is very difficult because it seems to be a disease that is unique to humans. Of course, when you think about the symptoms, delusions and hallucinations, it makes sense that animals that lack thought and speech would not manifest those. Our studies of schizophrenia, of course, depend upon the ability to study individuals with the illness, whether that be through imaging studies, where we can visualize the living brain in action, or through postmortem studies, by examining the brains of individuals who died with the illness and whose family members have generously donated their brain for study. But there are substantial limitations to how much we can learn from the direct study of the human brain because, of course, there are limits to how much we can control the study conditions. So a major area of importance in the study of the illness is the use of animal model systems, not where we have reproduced in animals the illness of schizophrenia, but where we have reproduced in animals some component of the disturbances in the brain that are present in individuals with the illness so that we can learn how those various disturbances relate to each another, and how medications that we might want to try in humans actually affect these changes that have been induced in the brains of animals.
schizophrenia, animal, model, system, organism, human, brain, gene, symptom, delusion, hallucination, david, lewis,
Professor David Lewis outlines how model organisms such as mice can help uncover the interplay of the genetic components in schizophrenia.
Professor David Lewis discusses how the diversity of symptoms in schizophrenia is reflected in the diversity of genetic and neural causes of the disorder.
An overview of schizophrenia-related content on Genes to Cognition Online.
Professor David Lewis explains that the symptoms of schizophrenia are typically defined as either positive or negative.
Professor David Lewis explains that positive symptoms of schizophrenia are currently more treatable than the negative symptoms.
Professor David Lewis explains that many schizophrenic individuals respond well to anti-psychotic medication. Treatment for other symptoms is developing.
Professor Jeffrey Lieberman discusses the dopamine hypothesis, the predominant neurochemical theory of schizophrenia.
Doctor Thomas Insel makes the case for model animals with the power to see how candidate genes for human disorders could affect other systems.
A review of the causes, symptoms, and treatments of schizophrenia.
An overview of bipolar disorder-related content on Genes to Cognition Online.