Hallmarks, Promoting mutations: Stillman
Bruce Stillman, Ph.D., president of Cold Spring Harbor Laboratory discusses that you need to acquire multiple changes in genes estimated to be about 5-7 genes perhaps on average, to get a full-blown cancer.
Bruce Stillman, Ph.D. is president and chief executive officer of Cold Spring Harbor Laboratory. He is interested in understanding the mechanism and control of DNA replication in higher cells. Working in baker's yeast, he has identified DNA sequences and proteins that interact to initiatiate chromosome duplication. â€œYou need to acquire multiple changes in the genes, multiple genes, to get a full-blown cancer estimates to be about 5-7 genes perhaps on average. Those changes accumulate over a period of time. Some of those changes accelerate the rate of accumulation of that. What is interesting is that some of them are inherited ahead of time. So BRCA-1 for instance, you are born with one of the niches already taken out of your belt and then to accumulate the other 4 or 5 changes, you are already on the way. And that is why there's a higher probability of getting cancer.â€
bruce stillman, mutations, cancer cells, genomic instability, brca 1, cancer
- ID: 952
- Source: DNALC.IC
Bruce Stillman, Ph.D., president of Cold Spring Harbor Laboratory, explains that genomic instability is a characteristic of cancer cells.
Matt Ridley talks about chromosome 13, BRCA2 gene for breast cancer susceptibility.
Mary-Claire King talks about testing for breast cancer.
Mary-Claire King reflects on how knowledge gained from the identification of BRCA1 and BRCA2 could lead to improved cancer treatments.
BRCA1, on chromosome 17, is one of the genes associated with hereditary breast cancer.
Bruce Stillman, Ph.D. is president and chief executive officer of Cold Spring Harbor Laboratory, explains that there are two adaptive immune responses, and those immune responses adapt to changes in cells in our body whether they be by infection or other.
BRCA2, on chromosome 13, is one of the genes associated with hereditary breast cancer
Bruce Stillman, Ph.D. is president and chief executive officer of Cold Spring Harbor Laboratory, discusses an area of immunology called adjuvant therapy, and how it is used to stimulate the body's immune system with agents that activate the immune system.
Mary-Claire King speaks about how much was yet to be understood about the genetic mechanisms of cancer when she began her hunt for genes associated with breast cancer.
Mary-Claire King talks about the value of using the centuries-old tool of family pedigrees to gain insight into patterns of inheritance of genetic disorders.