Hallmarks, Processing nutrients: Hanahan
Professor Douglas Hanahan discusses how cancer cells require a source of nutrients and oxygen, which is supplied through new blood vessel growth â€“ the process of angiogenesis, which is critical for almost all cancers.
In 2000, Douglas Hanahan (shown below) and Robert Weinberg published a paper in Cell, "The Hallmarks of Cancer," which identified some organizing principles of cancer cell development. â€œAs a cell, you need oxygen to breathe, the same way that the organism does. That dividing nest of cells will in some sense suffocate from lack of nutrients and oxygen and from their own waste unless they have a blood supply. It is now clear that induction and new blood vessel growth â€“ the process of angiogenesis â€“ is critical for almost all cancers, some less than others. Perhaps the leukemias and the blood-borne ones are less angiogenesis-dependent, but it may be that all cancers, in some sense, activate the vascular system to help support it.â€
oxygen, induction, organism, cancers, suffocate, blood supply, hallmarks, new blood, leukemias, vascular system, angiogenesis, source of nutrients, professor douglas, cancer cell, cancer cells, robert weinberg, blood vessel growth
- ID: 944
- Source: DNALC.IC
Professor Robert Weinberg explains how cancer cells have to learn how to become angiogenic, that is to say attract blood vessels to grow into the tumor mass.
Professor Robert Weinberg discusses how cancer cells have to learn how to avoid the process of programmed cell death known as apoptosis carried out in normal cells.
Professor Douglas Hanahan explains that a fundamental property of multi-cellular organisms is the capability to have cells commit suicide or undergo apoptosis, which is a form of programmed cell death.
Cancer is a disease that affects people of all nationalities and age groups and all cancers start with mutations in one cell.
Professor Robert Weinberg explains that cancer cells have to learn how to grow in the absence of growth stimulatory signals that normal cells require from their environment.
Professor Douglas Hanahan discusses how cancers kill you, in general, not just because they grow into a large lump, but because they invade into normal tissues and disrupt the functions of those tissues.
Cell division is essential for healthy growth of an organism and complex genetic mechanisms have evolved to switch cell division on and off at the proper time for normal development.
Professor Robert Weinberg, explains that cancer cells have to learn how to invade and metastasize.
Professor Douglas Hanahan discusses how cancer acquires capabilities and these capabilities are all, to some approximation, necessary to produce a successful tumor.
Professor Douglas Hanahan explains that not only are there positive signals that tell cells to grow but there are negative signals to stop such proliferation, and loss of the negative growth control signals is a common denominator for many cancers.