Hallmarks, Growing uncontrollably: Hanahan
Professor Douglas Hanahan explains that not only are there positive signals that tell cells to grow but there are negative signals to stop such proliferation, and loss of the negative growth control signals is a common denominator for many cancers.
In 2000, Douglas Hanahan (shown below) and Robert Weinberg published a paper in Cell, "The Hallmarks of Cancer," which identified some organizing principles of cancer cell development. â€œNot only are there positive signals that say grow but there are brakes which serve normally to stop such proliferation. And the loss of these growth control signals, these negative growth controls is again a common denominator for many cancers and this is separable in some sense from the growth stimulation, it's very much like putting your foot on the gas pedal, you put your foot on the gas pedal, the engine revs up, but if you've got your foot on the brake you still may not go anywhere. So these again are conceptually although they both relate to the ability of the cell to divide continuously they each have separable capabilities.â€
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- ID: 940
- Source: DNALC.IC
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Professor Douglas Hanahan discusses how cancer acquires capabilities and these capabilities are all, to some approximation, necessary to produce a successful tumor.
Professor Robert Weinberg discusses how cancer cells have to learn how to avoid the process of programmed cell death known as apoptosis carried out in normal cells.
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Professor Bert Vogelstein, explains that cancer is in essence a genetic disease. It is caused by mutations of genes and there are three types of genes, that contribute to cancer.
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