Professor Dennis Selkoe points out that although Alzheimer's disease is primarily a genetic disease, environmental factors such as exercise may be important.

So what are the environmental factors that could lead to Alzheimer’s [disease]? We think that one of them is exercise. Now every doctor in the world will tell you that exercise is wonderful for almost everything, and there is a lot of truth to that. Alzheimer's [disease], even though it’s not a disease of muscle and movement is no exception. Exercise seems to be associated, even in animal models where we express the amyloid parent protein and watch the amyloid build up in the memory centers of the brain, even there exercise lowers amyloid itself which is quite striking, and several scientists have done that. I haven’t worked on that myself.

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