Environmental factors and Alzheimer's disease
Professor Dennis Selkoe points out that although Alzheimer's disease is primarily a genetic disorder, environmental factors do contribute.
Weâ€™ve known for maybe 30 years, 40 years, even 50 years that there are genetic factors that lead to Alzheimerâ€™s disease, but the question comes up â€˜what about the Alzheimerâ€™s [disease] patients who donâ€™t have a clear cut family history?â€™ There are many people who get Alzheimerâ€™s [disease] in their 70â€™s, 80â€™s and beyond, and there is no knowledge that anyone else had it. We think that either that means itâ€™s a complex genetic trait, and no one gene is simply responsible and so it isnâ€™t a simple linear genetic inheritance, and/or there is an environmental factor that led that person to have Alzheimer's [disease] without a family history. I emphasize this issue of family history because actually most of the evidence suggests that genetics is the number one factor that leads to Alzheimerâ€™s [disease], and environmental factors seem to be less crucial. But it could well be, and I think it is, that certain genetic pre-dispositions donâ€™t automatically cause Alzheimerâ€™s disease 100% of the time, but interact with an environmental factor.
alzheimer, environment, environmental, factor, dennis, selkoe
Professor Dennis Selkoe points out that although Alzheimer's disease is primarily a genetic disease, environmental factors such as exercise may be important.
Professor Dennis Selkoe points out that although Alzheimer's disease is primarily a genetic disease, environmental factors may be preventative.
An overview of Alzheimer's disease-related content on Genes to Cognition Online.
Professor Dennis Selkoe discusses the degree to which the ApoE4 gene is associated with early onset Alzheimer's disease.
Professor Dennis Selkoe concludes that neurons are not the only type of cell affected in Alzheimer's disease.
Professor Dennis Selkoe discusses the age at which plaque-forming a-beta can begin to build up. Children with Down syndrome may have these plaques, otherwise childhood instances are rare.
Professor Dennis Selkoe discusses the largely linear relationship between a-beta and cell death in the brain.
Professor Dennis Selkoe discusses mild cognitive impaitment, a precursor to Alzheimer's disease. Early identification may be critical to treatment.
Professor Dennis Selkoe discusses the finding that amyloid beta seems to decrease the uptake of glutamate by synapses.
Professor Dennis Selkoe discusses an experiment by his group, which found that a-beta oligomers temporarily injected into rats' brains caused temporary forgetfulness.