A hypothetical snapshot of a cell's interior
Professor James Eberwine discusses what we might see were we to take a snapshot of the internal dynamics of a living cell, which might resemble Grand Central Station during rush hour.
One of the major areas of growth in neuroscience these days, combines neuroscience with genomics. The goal is to be able to understand gene expression and protein level abundances and dynamics within live cells. What we might envision would be RNAs being translated into proteins in different regions of the cell at different rates, because of different types of stimulation; you would expect to find RNAs made from the genomic DNA that would be targeted to different regions of the cell responding to different types of stimulation. It would just be a hodgepodge of activity like Grand Central Station during rush hour, where you would find molecules going all over the place but in a directed manner. In Grand Central Station people are going to their specific trains, in the cell RNAs and proteins are going to specific sites for functioning.
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Professor James Eberwine explains that gene expression within a cell is dynamic - changing in various ways as a cell ages.
Professor James Eberwine describes three ways in which experiences can change the gene-expression: changing RNA translation, movement, and potentially production.
Professor James Eberwine describes the primary functions of RNA-binding proteins, which include regulating tRNAs, degrading RNAs, synthesizing RNAs, and regulating multigenic gene expression.
Professor James Eberwine discusses the structural changes in a cell related to long-term potentiation. These include changes in the shape of dendritic spines.
Because it contains the directions for assembling the components of the cell, DNA is often thought of as the "instruction book" for assembling life.
Professor Rusty Lansford explains that dynamic imaging is important because it allows researchers to examine active development rather than interpreting a series of snapshots.
James Watson talks about the Central Dogma: transcription and translation.
James Watson talks about RNA's role in the cell.
The Central Dogma is the flow of genetic information from DNA, to RNA, to protein.
James Darnell explains how chemical signals turn eukaryotic genes on and off.