The neuropathology of depression and bipolar disorder
Professor James Potash discusses studies that show reductions in hippocampal volume in people with depression and abnormalities in cingulate areas in patients with bipolar disorder.
It would be extremely important to understand whether there are particular regions of the brain that are key in the pathology of depression and bipolar disorder. Iâ€™ll tell you that in the realm of depression it is pretty clear now; there have been 20 studies or so showing that the hippocampus is reduced in size in people with depression. In bipolar disorder the brain imaging studies have not shown any particular region to be consistently abnormal in size or in volume. There are some studies showing abnormal activity in certain bipolar disorder regions; the cingulate (anterior cingulate gyrus) for example is one.
neuropathology, anterior cingulate gyrus, hippocampus, bipolar disorder, depression, james, potash
An overview of bipolar disorder-related content on Genes to Cognition Online.
An overview of depression-related content on Genes to Cognition Online.
Professor James Potash explains that, for many bipolar disorder patients, managing medications can be difficult.
Professor James Potash explains that bipolar disorder is episodic: people get ill, then they get well again and then the illness may come back again at a later date.
Professor James Potash discusses evidence from a number of studies that individuals with mood disorders are more likely to be highly creative.
Professor James Potash explains that most individuals with bipolar disorder lead normal lives and respond well to lithium medication.
Professor James Potash describes how the diathesis-stress model can be used to understand interactions between genes and the environment. He refers specifically to bipolar disorder.
Professor James Potash explains that twin studies dating back to the 1920s have identified bipolar disorder as a genetic disorder.
Professor James Potash discusses the dramatic increase in the rates of diagnosis of childhood bipolar disorder, which has risen forty-fold in recent years.
Professor James Potash describes how endophenotypes are used to study bipolar disorder. Endophenotypes are essentially subtypes of larger symptoms.