Bipolar disorder and twin studies
Professor James Potash explains that twin studies dating back to the 1920s have identified bipolar disorder as a genetic disorder.
So there have been studies going back to the 1920s demonstrating that manic depressive insanity, as it was originally called, has a genetic basis. There were studies in the 1920s in Germany that showed that manic depression runs in families, and also showing that identical twins are more likely to share both having the illness than are fraternal twins. That suggests the genetic basis for the illness since identical twins share 100 percent of their DNA and fraternal twins only 50 percent. In the modern era there have been many more studies of that sort â€“ family studies showing that bipolar disorder and depression run in families and twin studies showing that increased sharing or concordance as we call it in identical twins as compared to fraternal. There have also been a couple of adoption studies showing that the biological parents of adoptees with the mood disorder are more likely to have the illness than are the adoptive parents. So all of those sorts of studies have very firmly established that there is a genetic basis to these illnesses, now we are at the point of trying to figure out what exactly are the genetic variations.
bipolar disorder, manic depression, genetic basis, genes, twin study, studies, adoptees, 1920s, insanity, james potash
An overview of bipolar disorder-related content on Genes to Cognition Online.
Professor James Potash discusses studies that show reductions in hippocampal volume in people with depression and abnormalities in cingulate areas in patients with bipolar disorder.
Professor James Potash discusses evidence from a number of studies that individuals with mood disorders are more likely to be highly creative.
Professor James Potash describes how the diathesis-stress model can be used to understand interactions between genes and the environment. He refers specifically to bipolar disorder.
Professor James Potash explains that, for many bipolar disorder patients, managing medications can be difficult.
A review of the symptoms, causes, diagnosis, and treatments of bipolar disorder.
Kay Jamison discusses how the idea of bipolar disorder as a genetic illness affected her life.
Professor James Potash explains that bipolar disorder is episodic: people get ill, then they get well again and then the illness may come back again at a later date.
Professor James Potash describes how endophenotypes are used to study bipolar disorder. Endophenotypes are essentially subtypes of larger symptoms.
"Chart of the C____ Family," insanity and manic depression pedigree