Francois Jacob, Cold Spring Harbor, 1953 meeting. Source: Cold Spring Harbor Laboratory Archives.
François Jacob (1953) and Jacques Monod
Francois Jacob draws out the control mechanism he co-discovered.
Sydney Brenner, Francois Jacob and Matt Meselson's experiment showed that RNA was a copy of the information in DNA. As a messenger, RNA transported the information from the nucleus to the protein-making machinery in the cell.
Francois Jacob and Jacques Monod figured out how bacteria controlled the production of an enzyme called beta-galactosidase. This system of feedback and negative regulation became the lac operon and was the first model for the control of protein productio
Francois Jacob and Jacques Monod were the first to discover how genes were turned on and off.
Small image of Francois Jacob's lac operon drawing.
The first model for the control of protein production was the lac operon. This system of feedback and negative regulation is used by bacteria, however, the general principles also apply to higher organisms. Another method of protein regulation involves
Matt Meselson also had a hand in Sydney Brenner's RNA experiment. He talks about the experiment and how they waited for James Watson's group to finished their RNA work before publishing.
Jacques Monod and Francois Jacob work with how bacteria breaks large sugars into smaller pieces.