The lac operon
Francois Jacob and Jacques Monod figured out how bacteria controlled the production of an enzyme called beta-galactosidase. This system of feedback and negative regulation became the lac operon and was the first model for the control of protein production. Walter Gilbert and his group later isolated the lac operon repressor.
francois jacob and jacques monod,lac operon,jacques monod,francois jacob,beta galactosidase,protein production,walter gilbert,first model,repressor,bacteria
- ID: 15884
- Source: DNALC.DNAi
The first model for the control of protein production was the lac operon. This system of feedback and negative regulation is used by bacteria, however, the general principles also apply to higher organisms. Another method of protein regulation involves
François Jacob (1953) and Jacques Monod
Francois Jacob and Jacques Monod were the first to discover how genes were turned on and off.
Jacques Monod and Francois Jacob work with how bacteria breaks large sugars into smaller pieces.
Jacques Monod and Francois Jacob were the first to discover how genes were turned on and off.
François Jacob talks about bacterial mutants that could not metabolize lactose. Using these mutants, Jacob and Monod figured out how protein production is controlled.
Small image of Francois Jacob's lac operon drawing.
François Jacob talks about Genes control the structure of proteins
François Jacob explains why Jacques Monod chose to work with the lactose system.
François Jacob talks about the relationship between DNA, ribosomes, and protein production.