The discovery of the lac operon, Fran�ois Jacob
Interviewee: Fran�ois Jacob. François Jacob talks about how enzyme production was viewed at the time they were beginning their experiments. (DNAi Location: Code > Controlling the code > Players > Fran�ois Jacob and Jacques Monod > Induction vs. adaptation)
You have to recall that until the war there was no question of genes in bacteria. Genes in bacteria came off two series of work, one was the analysis of bacterial mutations by Luria and Delbruck, and the other was a combination by Lederberg and Tatum, and this was '46, '47. So the, it was called, at that time, it was not called induction, it was called adaptation, it was that bacteria put from glucose to galactose, took a while and then make the enzyme and they became adapted to eat lactose. And then adaptation became a very bad word, because it was, it, it showed very different things, so they, they stopped to call it adaptation and call enzyme induction, which is production of enzyme, and it took a number of experiments to, to put the gene into the picture.
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François Jacob talks about the relationship between DNA, ribosomes, and protein production.
François Jacob explains why Jacques Monod chose to work with the lactose system.
François Jacob talks about bacterial mutants that could not metabolize lactose. Using these mutants, Jacob and Monod figured out how protein production is controlled.
Jacques Monod and Francois Jacob work with how bacteria breaks large sugars into smaller pieces.
Learn more about the lac operon system.
François Jacob talks about Genes control the structure of proteins
François Jacob, Sydney Brenner and Matt Meselson worked on the role of mRNA. An on/off switch involving mRNA seemed a logical control point for protein production.
Walter Gilbert talks about identifying the lac operon repressor.
François Jacob talks about designing bacteria.
Francois Jacob and Jacques Monod figured out how bacteria controlled the production of an enzyme called beta-galactosidase. This system of feedback and negative regulation became the lac operon and was the first model for the control of protein productio