François Jacob (1953) and Jacques Monod
François Jacob, Cold Spring Harbor, 1953 meeting. Source: Cold Spring Harbor Laboratory Archives.
Francois Jacob and Jaçques Monod figured out how bacteria controlled the production of an enzyme called beta-galactosidase. This system of feedback and negative regulation became the lac operon and was the first model for the control of protein productio
Sydney Brenner, François Jacob and Matt Meselson's experiment showed that RNA was a copy of the information in DNA. As a messenger, RNA transported the information from the nucleus to the protein-making machinery in the cell.
François Jacob draws out the control mechanism he co-discovered.
The first model for the control of protein production was the lac operon. This system of feedback and negative regulation is used by bacteria, however, the general principles also apply to higher organisms. Another method of protein regulation involves
François Jacob, 1985.
Matt Meselson also had a hand in Sydney Brenner's RNA experiment. He talks about the experiment and how they waited for James Watson's group to finished their RNA work before publishing.
Small image of François Jacob's lac operon drawing.
François Jacob at a Cold Spring Harbor meeting, 1953.