The Philadelphia chromosome is an abnormal chromosome that results from the exchange of portions of genetic material from chromosomes 9 and 22. A mutant gene formed by this exchange codes for a protein whose action causes chronic myeloid leukemia (CML).
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- ID: 15706
- Source: DNALC.DNAi
15994. The chronic myeloid leukemia (CML) mutation
View the animation to learn about the Philadelphia chromosome, the abnormal chromosome that causes chronic myeloid leukemia.
1013. Diagnosis, Targeted therapies: Targeting activators, Sawyer 1
Professor Charles Sawyer explains that CML stands for chronic myeloid leukemia, which is a blood cancer and it is different from many cancers because it starts very slowly and patients when they're first diagnosed don't have many symptoms.
15525. How Gleevec works to alleviate symptoms of myeloid leukemia, 3D animation with basic narration
View the animation to find out how the drug Gleevecâ¢ inhibits the molecular cause of chronic myeloid leukemia.
1012. Diagnosis, Targeted therapies: Targeting activators
In this section learn that tyrosine kinases are a family of activator proteins that trigger the cell signaling process leading to cell growth and division.
15055. Using DNA science to control CML, Brian Druker
Brian Druker talks about how the drug he designed targets the molecular cause of CML.
15413. Chromosome 18: BCL2 oncogene, Matt Ridley
Matt Ridley talks about chromosome 18, BCL2 oncogene.
1010. Diagnosis, Targeted therapies
Conventional cancer drugs are cellular poisons that block replication or some other aspect of cell growth. These drugs affect all cells – healthy or cancerous.
15041. Getting the diagnosis of chronic myeloid leukemia, Bud
Bud recounts receiving the diagnosis that he had chronic myeloid leukemia.
15954. What is Leukemia?
BCL-2 is associated with the development of certain forms of leukemia that affect B-cells. If the gene is swapped onto a different chromosome, its protein is over-produced, resulting in B cells that do not function or self-destruct as they should.
15082. Shutting down cancer with Gleevec, Brian Druker
Brian Druker reflects on the importance of understanding the causes of cancer for developing new treatments.