Shutting down cancer with Gleevec, Brian Druker
Interviewee: Brian Druker. Brian Druker reflects on the importance of understanding the causes of cancer for developing new treatments. (DNAi Location: Applications > Genes and medicine > Drug design > Brian Druker > Shutting down cancer)
If you look back at the history of cancer research, in many respects for 30 or 40 years we've been stumbling around in the dark. We understood that cancer is probably a genetic disease but what those genetic abnormalities are that caused the uncontrolled growth of cancer in most cases remain elusive. With Gleevec we've shown that if you understand what drives the growth of a cancer you can shut it down specifically.
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Brian Druker talks about the drug he developed as a turning point in the war on cancer.
Brian Druker talks about how the drug he designed targets the molecular cause of CML.
Brian Druker talks about how Gleevec has restored patients' hope for the future.
15525. How Gleevec works to alleviate symptoms of myeloid leukemia, 3D animation with basic narration
View the animation to find out how the drug Gleevecâ¢ inhibits the molecular cause of chronic myeloid leukemia.
Brian Druker credits the drug company Novartis with recognizing the importance of Gleevec and accelerating the development and approval process.
Yvonne, Bud's wife, talks about the first day of the clinical trials in June of 1998.
Bud recounts receiving the diagnosis that he had chronic myeloid leukemia.
Professor Charles Sawyer explains that CML stands for chronic myeloid leukemia, which is a blood cancer and it is different from many cancers because it starts very slowly and patients when they're first diagnosed don't have many symptoms.
A mutation that gives rise to the Philadelphia chromosome gives rise to leukemia.
View the animation to learn about the Philadelphia chromosome, the abnormal chromosome that causes chronic myeloid leukemia.