The chronic myeloid leukemia (CML) mutation
A mutation that gives rise to the Philadelphia chromosome gives rise to leukemia.
Professor Charles Sawyer explains that CML stands for chronic myeloid leukemia, which is a blood cancer and it is different from many cancers because it starts very slowly and patients when they're first diagnosed don't have many symptoms.
15525. How Gleevec works to alleviate symptoms of myeloid leukemia, 3D animation with basic narration
View the animation to find out how the drug Gleevecâ¢ inhibits the molecular cause of chronic myeloid leukemia.
Bud and Yvonne are delighted by Bud's recovery thanks to Gleevec
Brian Druker is a professor at Oregon Health Sciences University.
Bud recounts receiving the diagnosis that he had chronic myeloid leukemia.
In this section learn that tyrosine kinases are a family of activator proteins that trigger the cell signaling process leading to cell growth and division.
Brian Druker talks about how the drug he designed targets the molecular cause of CML.
Professor Charles Sawyer explains that Gleevec is a pill taken once a day and works remarkably well in all phases of CML.
Professor Charles Sawyer explains that the CML clone makes mistakes in DNA replication and generates a diverse repertoire of mutations.