The chronic myeloid leukemia (CML) mutation

View the animation to learn about the Philadelphia chromosome, the abnormal chromosome that causes chronic myeloid leukemia.

chronic myeloid leukemia,philadelphia chromosome,abnormal chromosome,cml,leukemia,mutation,animation

  • ID: 15994
  • Source: DNALC.DNAi

Related Content

15706. Philadelphia chromosome

A mutation that gives rise to the Philadelphia chromosome gives rise to leukemia.

  • ID: 15994
  • Type: animation
  • Source: DNAi

1013. Diagnosis, Targeted therapies: Targeting activators, Sawyer 1

Professor Charles Sawyer explains that CML stands for chronic myeloid leukemia, which is a blood cancer and it is different from many cancers because it starts very slowly and patients when they're first diagnosed don't have many symptoms.

  • ID: 15994
  • Type: animation
  • Source: IC

15525. How Gleevec works to alleviate symptoms of myeloid leukemia, 3D animation with basic narration

View the animation to find out how the drug Gleevec™ inhibits the molecular cause of chronic myeloid leukemia.

  • ID: 15994
  • Type: animation
  • Source: DNAi

15712. Bud and Yvonne

Bud and Yvonne are delighted by Bud's recovery thanks to Gleevec

  • ID: 15994
  • Type: animation
  • Source: DNAi

15714. Brian Druker

Brian Druker is a professor at Oregon Health Sciences University.

  • ID: 15994
  • Type: animation
  • Source: DNAi

15041. Getting the diagnosis of chronic myeloid leukemia, Bud

Bud recounts receiving the diagnosis that he had chronic myeloid leukemia.

  • ID: 15994
  • Type: animation
  • Source: DNAi

1012. Diagnosis, Targeted therapies: Targeting activators

In this section learn that tyrosine kinases are a family of activator proteins that trigger the cell signaling process leading to cell growth and division.

  • ID: 15994
  • Type: animation
  • Source: IC

15055. Using DNA science to control CML, Brian Druker

Brian Druker talks about how the drug he designed targets the molecular cause of CML.

  • ID: 15994
  • Type: animation
  • Source: DNAi

1014. Diagnosis, Targeted therapies: Targeting activators, Sawyer 2

Professor Charles Sawyer explains that Gleevec is a pill taken once a day and works remarkably well in all phases of CML.

  • ID: 15994
  • Type: animation
  • Source: IC

1015. Diagnosis, Targeted therapies: Targeting activators, Sawyer 3

Professor Charles Sawyer explains that the CML clone makes mistakes in DNA replication and generates a diverse repertoire of mutations.

  • ID: 15994
  • Type: animation
  • Source: IC