What is Leukemia?

BCL-2 is associated with the development of certain forms of leukemia that affect B-cells. If the gene is swapped onto a different chromosome, its protein is over-produced, resulting in B cells that do not function or self-destruct as they should.

chromosome 18,b cells,forms of leukemia,self destruct,leukemia,protein

  • ID: 15954
  • Source: DNALC.DNAi

Related Content

15413. Chromosome 18: BCL2 oncogene, Matt Ridley

Matt Ridley talks about chromosome 18, BCL2 oncogene.

  • ID: 15413
  • Source: DNAi

15706. Philadelphia chromosome

A mutation that gives rise to the Philadelphia chromosome gives rise to leukemia.

  • ID: 15706
  • Source: DNAi

15994. The chronic myeloid leukemia (CML) mutation

View the animation to learn about the Philadelphia chromosome, the abnormal chromosome that causes chronic myeloid leukemia.

  • ID: 15994
  • Source: DNAi

15525. How Gleevec works to alleviate symptoms of myeloid leukemia, 3D animation with basic narration

View the animation to find out how the drug Gleevec™ inhibits the molecular cause of chronic myeloid leukemia.

  • ID: 15525
  • Source: DNAi

15055. Using DNA science to control CML, Brian Druker

Brian Druker talks about how the drug he designed targets the molecular cause of CML.

  • ID: 15055
  • Source: DNAi

1013. Diagnosis, Targeted therapies: Targeting activators, Sawyer 1

Professor Charles Sawyer explains that CML stands for chronic myeloid leukemia, which is a blood cancer and it is different from many cancers because it starts very slowly and patients when they're first diagnosed don't have many symptoms.

  • ID: 1013
  • Source: IC

1012. Diagnosis, Targeted therapies: Targeting activators

In this section learn that tyrosine kinases are a family of activator proteins that trigger the cell signaling process leading to cell growth and division.

  • ID: 1012
  • Source: IC

1010. Diagnosis, Targeted therapies

Conventional cancer drugs are cellular poisons that block replication or some other aspect of cell growth. These drugs affect all cells – healthy or cancerous.

  • ID: 1010
  • Source: IC

15041. Getting the diagnosis of chronic myeloid leukemia, Bud

Bud recounts receiving the diagnosis that he had chronic myeloid leukemia.

  • ID: 15041
  • Source: DNAi

15958. What causes muscular dystrophy?

The DMD gene codes for a large protein called dystrophin that is necessary for muscle cells to maintain their shape.

  • ID: 15958
  • Source: DNAi