Matthew Meselson (1958)
The last graduate student Linus Pauling ever had. Unconcerned by reputations, Meselson did what he was interested in. Along with Franklin Stahl, Meselson carried out what many biologists regard as "one of the most beautiful experiments in biology."
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- ID: 15700
- Source: DNALC.DNAi
Matthew Meselson and Franklin Stahl invented the technique of density gradient centrifugation and used this to prove that DNA is replicated semi-conservatively.
Franklin Stahl and Matthew Meselson invented the technique of density gradient centrifugation and used this to prove that DNA is replicated semi-conservatively.
Describing how he first met Matthew Meselson.
Describing his first meeting with James Watson and Matthew Meselson.
Matt Meselson talks about the different models that were considered before their experiment.
Recounting how the seminal "Meselson-Stahl" experiment was only performed 3 times, with one set of results discarded due to mislabelled tubes!
The three models of DNA replication - semi-conservative, conservative, and dispersive - and whether bias played a role in designing/interpreting the experiment.
James Watson talks about who he thinks should have won the Nobel Prize in 1962.
Matt Meselson talks about how he met Frank Stahl, his partner in "the beautiful experiment." Together they proved that DNA is replicated semi-conservatively.
On whether, upon completing their seminal experiment, Max DelbrÃ¼ck locked Meselson and Stahl in a cabin to force them to write up their results for publishing - how the great scientists are always looking to the "next result."