Proposed models of DNA replication, Matthew Meselson
Interviewee: Matt Meselson. Matt Meselson talks about the different models that were considered before their experiment. (DNAi Location: Code > Copying the code > Players > Matthew Meselson > Models of DNA replication)
Well we tried to find out if DNA replicates semi-conservatively or dispersively or conservatively. And that means do the two strands separate but remain as single strands indefinitely, and each become associated with a newly synthesized strand at each generation; or do they come apart and get dispersed, or do they stay together the two strands indefinitely, making only brand new DNA molecules alongside themselves.
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Matt Meselson describes the experiment he did with Frank Stahl to prove that DNA is replicated semi-conservatively.
Matt Meselson and Frank Stahl's
Three different models of DNA replication were proposed. Matt Meselson and Frank Stahl's experiment supported only one of the models.
Matt Meselson talks about how he and Frank were "encouraged" by Max Delbruck to write up the results of their experiment on semi-conservative DNA replication.
Explore other theories on DNA replication.
Matthew Meselson and Franklin Stahl show how new DNA is made by copying the old.
Matt Meselson talks about how he met Frank Stahl, his partner in "the beautiful experiment." Together they proved that DNA is replicated semi-conservatively.
James Watson talks about who he thinks should have won the Nobel Prize in 1962.
Matthew Meselson and Franklin Stahl invented the technique of density gradient centrifugation and used this to prove that DNA is replicated semi-conservatively.
See how information in DNA is copied to make new DNA molecules.