How the second paper (on the replication of DNA) was written, Matthew Meselson
Interviewee: Matt Meselson Matt Meselson talks about how he and Frank were "encouraged" by Max Delbruck to write up the results of their experiment on semi-conservative DNA replication. (DNAi Location: Code > Copying the code > Players > Matt Meselson > Writing the paper)
The second paper was on the replication of DNA and we took a long time to write it, we wanted to do a lot of things just right, and Max was getting quite impatient. And Caltech owns a wonderful marine station at Corona del Mar I think it is, and there's a tower on that building which is a little office and as I recall there is a bathroom, I think, and Max was, Max was always wonderfully dramatic about things, and he locked us in and said we're not going to let you out, paper's done. As I remember I think we got let out at night, each night. But Manny would bring the food, Max's wife Manny, to the door and somehow, I don't know, maybe they unlocked the door and put it under, I don't remember too clearly. But Frank and I worked on the paper, we didn't actually quite finish it, but we got it basically done and that was that.
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Matt Meselson talks about the different models that were considered before their experiment.
Matt Meselson describes the experiment he did with Frank Stahl to prove that DNA is replicated semi-conservatively.
Matt Meselson and Frank Stahl's
Matt Meselson talks about how he met Frank Stahl, his partner in "the beautiful experiment." Together they proved that DNA is replicated semi-conservatively.
Franklin Stahl and Matthew Meselson invented the technique of density gradient centrifugation and used this to prove that DNA is replicated semi-conservatively.
Matthew Meselson and Franklin Stahl invented the technique of density gradient centrifugation and used this to prove that DNA is replicated semi-conservatively.
James Watson talks about who he thinks should have won the Nobel Prize in 1962.
Three different models of DNA replication were proposed. Matt Meselson and Frank Stahl's experiment supported only one of the models.
How Meselson came to read the Watson and Crick paper, then think about ways to experimentally test how DNA replicates.
Matthew Meselson and Franklin Stahl show how new DNA is made by copying the old.