The data structure of the human genome: poetry or prose?, Jim Kent
Interviewee: Jim Kent. The data structure of the human genome: poetry or prose?
Then another thing that makes, makes DNA assembly a challenge is that the human genome is actually in fact is not really like prose. In some ways it's more like poetry, or a song even, in that it has a lot of repeating elements. And so you can imagine, say you were trying to assemble Mary Had a Little Lamb from pieces. You'd have "Mary had a little lamb, little lamb, little lamb, Mary had a little lamb whose fleece was white as snow", okay. Well then, if you just had the phrase "little lamb", where are you going to put that in this song? You can put it here, you could put it here, you could put it here, you just don't know. And it's actually the single thing that makes the assembly difficult is coping with the repeats.
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Jim Kent, the author of the assembly program for the public sequence, talks about the difficulties of reassembling small pieces of the genome when there are so many repeat sequences.
Jim Kent talks about a farm of computers.
Jim Kent talks about dealing with sequencing data.
Jim Kent talks about junk DNA in the human genome.
Jim Kent, the author of the assembly program for the public sequence, talks about the challenge of reassembling the genome.
Jim Kent talks about the difficulties of DNA assembly.
Leroy Hood talks about audacious idea of sequencing the human genome.
Jim Kent talks about transposons and repetitive elements in the human genome.
James Watson describes sequencing the human genome using markers and BACs, and Craig Venter explains using cDNA libraries, ESTs, and shotgun sequencing.
Ewan Birney talks about developing programs that look at DNA sequence.