The difficulties of DNA assembly, Jim Kent
Interviewee: Jim Kent. The difficulties of DNA assembly.
What makes DNA assembly maybe more challenging even than Russian prose is that it can actually be read forward and backwards, and so you have to see if it goes this way, or and if it doesn't go this way, maybe it goes that way. And this, this bit actually was, was particularly hard for me because I had a little bit of dyslexia when I was a kid and I was always getting my letters reversed. And so does it go this way or that way and I don't know it was kind of confusing too. I would all the time be getting things backwards and would just have to proceed by trial and error. Fortunately there would be only two cases, you know, if it wasn't this way then, well, just swap the sign and maybe it'll work that way.
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Jim Kent, the author of the assembly program for the public sequence, talks about the difficulties of reassembling small pieces of the genome when there are so many repeat sequences.
Jim Kent talks about a farm of computers.
Jim Kent talks about the data structure of the human genome: poetry or prose?
Jim Kent, the author of the assembly program for the public sequence, talks about the challenge of reassembling the genome.
Jim Kent talks about junk DNA in the human genome.
Jim Kent talks about cell division and DNA.
Jim Kent talks about dealing with sequencing data.
Jim Kent talks about telomeres and cell death.
Ewan Birney, a key figure in the public sequence analysis, talks about trying to find meaning in the sequence.
Jim Kent talks about banding appears in dyed chromosomes.