Finding genes, Ewan Birney
Interviewee: Ewan Birney. Finding gene.
For the first draft of the genome sequence, both teams were working to identify the number of human genes. Here, Ewan Birney, a "numbers man" from the public genome project, explains how genes can be recognized and the data from the genome project used. We're writing computer programs that do that. In fact it's very similar to speech recognition software that people use in, in you know, other fields, say in the telephone industry. So it's very much like a recognition, we're trying to recognize now not parts of speech but parts of DNA that show you where the genes are. So genes start in a particular way and they end in a particular way, and we know some way about how they're put together in the middle. And so we kind of build a mathematical model of how a gene looks, using these techniques.
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For the first draft of the genome sequence, both teams were working to identify the number of human genes. Here, Ewan Birney, a "numbers man" from the public genome project, explains how genes can be recognized and the data from the genome project used.
Ewan Birney talks about developing programs that look at DNA sequence.
Ewan Birney, one of the leading analysts involved in the Human Genome Project, takes you on an informal tour of a chromosome.
Shotgun sequencing and dealing with repeat sections.
Ari Patrinos talks about the first draft of the human genome.
Ewan Birney, a key player in the computing and analysis of the genome, reflects on the implications of the Human Genome Project for biology.
James Watson describes sequencing the human genome using markers and BACs, and Craig Venter explains using cDNA libraries, ESTs, and shotgun sequencing.
Craig Venter talks about using computers to predict how genes within the human genome.
Craig Venter, the leader of the private genome effort, talks about the "whole genome shotgun" technique that was used by Celera Genomics to sequence the human genome.
Our genome is a set of long DNA molecules containing tens of thousands of genes.