Using computers to predict how genes within the human genome, Craig Venter

Interviewee: Craig Venter. Craig Venter talks about using computers to predict how genes within the human genome.

Back when we were doing the first test project for sequencing the human genome, the best mathematical tools could only deal with a thousand sequences, and nobody thought you'd ever need anything more than that because that's how the genomes were going to be sequenced, as serial versions of these tiny projects. But all of a sudden we had hundreds of thousands of sequences that we need to coalesce to find out how many human genes there were, what the redundancy and the sequencing was, etc. So we hired some computer scientists and mathematicians, the senior one at the time was Granger Sutton, who built an algorithm that ended up being called the Tiger Assembler. And it was designed to put all these hundreds of thousands of EST CDNA sequences together to guess how many human genes there were.

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