Implications of recombinant DNA work, Herbert Boyer
Interviewee: Herbert Boyer. Herb Boyer reflects on the importance of their work on rDNA technology and its impact on understanding the genetics of higher organisms. (DNAi Location: Manipulation > Revolution > Players > Herbert Boyer and Stanley Cohen > Implications of their work)
Well the implication is that you could do molecular biology on the chromosomes of higher organisms, you could understand the genetics in the detail that had been established for animal viruses, bacterial viruses and, and the bacterial chromosome. 'Course it's, it's come such a long, gone way beyond that now, but those were the immediate implications that it was a breakthrough into understanding the genetics of higher organisms or what we call eukaryotic organisms, non-bacterial.
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Herb Boyer talks about Stanley Cohen's and his interest in plasmids as vectors for DNA.
Stanley Cohen and Herbert Boyer transform bacteria with a recombinant plasmid, and Doug Hanahan studies induced transformation.
Stanley Cohen speaks about his and Herbert Boyer's experiment to make the first plasmid that had been engineered to contain foreign DNA.
Stanley Cohen and Herbert Boyer's historic experiment used techniques to cut and paste DNA to create the first custom-made organism containing recombined or "recombinant" DNA.
Stanley Cohen talks about the challenge of isolating and studying individual genes.
Herbert Boyer: Former varsity lineman turned biotech bigwig. Expert at cutting DNA before most people knew it could be done. Stanley Cohen: A born tinkerer; figured out the trick of using loops of DNA called plasmids to transform bacterial DNA
Image of Herbert Boyer. From lineman on the varsity football team to co-founder of the first biotech company, Boyer has never lacked imagination, drive, or vision. His and Stanley Cohen's recombinant DNA work paved the way for the biotech revolution.
Stanley Cohen and Herbert Boyer inserted the recombinant DNA molecule they created into E. coli bacteria by means of a plasmid, thereby inducing the uptake and expression of a foreign DNA sequence known as "transformation."
Herb Boyer and Stan Cohen "invented" recombinant DNA technology.