Professor Eric Kandel explains how a protein called CPB may have a built-in memory mechanism that can help long-term memory storage.
There is quite good evidence that there is a regulator of local protein synthesis called the cytoplasmic polyadenylation element binding agent protein CPB. And we have obtained evidence that this has extremely interesting properties. It can be self-maintaining, it can have a memory mechanism built into itself. It acts like a prion protein, prions are self-maintained protein machines, they can perpetuate themselves but unlike conventional prions (which cause disease, like mad cow disease or Jakob Creutzfeldt disease), this is a prion mechanism that we think is only used in a beneficial way to store long-term memory. But, this is not yet definitively shown - this is in the process of being explored.
cbp, cytoplasmic, polyadenylation, binding, protein, synthesis, prion, memory, long, term, store, storage, eric, kandel,
Professor Eric Kandel discusses the importance of the hippocampus in the formation of long-term memories.
Professor Eric Kandel explains that the CA1 region of the hippocampus is important for representing and remembering spaces.
Professor Eric Kandel compares short-term memory, which involves the alteration of pre-existing proteins, and long-term memory, which involves new protein synthesis.
Professor Eric Kandel discusses changes in synapse structure during long-term memory. Research indicates these changes are synapse-specific and not neuron-wide.
Professor Eric Kandel discusses the importance of attention in forming declarative/explicit memories. These memories involve the hippocampus.
Professor Eric Kandel explains that events in the environment can have profound effects on gene expression and brain anatomy.
CAMP response element-binding protein 2(CREB2) is also known as Activating Transcription Factor 2 (ATF2). CREB2 is a CREB repressor, which means it inhibits long-term memory formation.
The hippocampus is closely aligned to memory formation. It is an important early storage place for long–term memory, and is involved in the transition to more enduring permanent memory.
Professor Eric Kandel introduces the concept of long-term potentiation, which refers to change in the strength of synaptic connections.
Doctor Josh Dubnau explains that memories seem to be formed in different stages that evolve over time. These include acquisition, short-term storage, and consolidation.