Glutamate Hypothesis of Schizophrenia
Professor Jeffrey Lieberman discusses the glutamate hypothesis of schizophrenia. The drug PCP acts on glutamate receptors, producing schizophrenia-like symptoms.
The second neurochemical hypothesis of schizophrenia is the glutamate hypothesis. Now glutamate is also a neurotransmitter. It's a chemical that is in the brain that is secreted into synapses and facilitates nerve impulse propagation. Glutamate stimulates a receptor, a group of receptors. Now there is a recreational drug that is frequently used called PCP, phencyclidine, angel dust. And it was observed that this drug, when people take it, makes them have symptoms, makes them act like they have schizophrenia. Turns out that PCP acts at one of the receptors that glutamate stimulates to block the affects of glutamate. As a result of that, we now believe that one of the reasons why schizophrenia occurs is because people with schizophrenia have a deficiency or a defect in this receptor and the receptor cannot be properly stimulated by glutamate.
schizophrneia, glutamate, hypothesis, PCP, phencyclidine, neurotransmitter, synapse, schizophrenia, hypothesis, neurotransmitter, receptor, jeffrey, lieberman,
Professor Jeffrey Lieberman discusses the dopamine hypothesis, the predominant neurochemical theory of schizophrenia.
Professor Jeffrey Lieberman discusses the serotonin hypothesis of schizophrenia. Drugs such as LSD and ecstasy block serotonin and produce schizophrenia-like symptoms.
Professor Daniel Weinberger discusses evidence from a number of research areas that highlight the importance of the neurotransmitter glutamate in schizophrenia.
An overview of schizophrenia-related content on Genes to Cognition Online.
Professor Seth Grant explains that NMDA is an amino acid derivative very similar to glutamate - the brain's primary excitatory neurotransmitter.
Metabotropic Glutamate Receptor-3 (GRM3) is a candidate gene for schizophrenia.
Professor Jeffrey Lieberman discusses the differences between typical and atypical drugs that are used to treat schizophrenia.
Professor Tom O'Dell comments that phosphorylation plays a crucial role in synaptic plasticity.
Professor Jeffrey Lieberman discusses the hypothesis that schizophrenia is caused by a group of genes producing abnormalities in brain development.
Doctor Jon Lieberman discusses three neurotransmitters that have been associated with depression - dopamine, serotonin, and norepinephrine.