Serotonin Hypothesis of Schizophrenia
Professor Jeffrey Lieberman discusses the serotonin hypothesis of schizophrenia. Drugs such as LSD and ecstasy block serotonin and produce schizophrenia-like symptoms.
The third neurochemical hypothesis of schizophrenia is the serotonin hypothesis. And this, like the dopamine and the glutamate hypotheses, derived, in part, from observations about the pharmacology of drugs that were used recreationally, specifically hallucinogenic or psychotomimetic drugs, like LSD, mescaline, psilocybin, ecstasy. These drugs all acted by blocking the affects of serotonin at specific receptors and therefore it was reasoned that if it can produce these amazing changes in the mind and mental processes and behavior, then maybe internal processes in the brains of people with schizophrenia were occurring that were producing the symptoms of the illness.
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An overview of schizophrenia-related content on Genes to Cognition Online.
Professor Jeffrey Lieberman discusses the dopamine hypothesis, the predominant neurochemical theory of schizophrenia.
Professor Jeffrey Lieberman discusses the glutamate hypothesis of schizophrenia. The drug PCP acts on glutamate receptors, producing schizophrenia-like symptoms.
Serotonin is a neurotransmitter associated with a number of cognitive disorders, namely depression, bipolar and schizophrenia. Professor Trevor Robbins explains how the serotoninergic system works.
Professor Jeffrey Lieberman discusses the differences between typical and atypical drugs that are used to treat schizophrenia.
Doctor Jon Lieberman discusses three neurotransmitters that have been associated with depression - dopamine, serotonin, and norepinephrine.
Professor Daniel Weinberger discusses evidence from a number of research areas that highlight the importance of the neurotransmitter glutamate in schizophrenia.
Many psychiatrists are now prescribing second-generation or 'atypical' antipsychotics.
Professor Philip Shaw discusses some medications use to treat ADHD, which lead to improvements in up to 90% of children.
Serotonin is the biochemical most commonly associated with depression. Professor Wayne Drevets discusses other systems including norepinephrine, glutamate, and dopamine.