Brain Cells in Schizophrenia - Faulty Circuits?
Professor Jeffrey Lieberman discusses the hypothesis that schizophrenia is caused by a group of genes producing abnormalities in brain development.
It is generally believed, and there is a lot of evidence to support the fact, that the cause of schizophrenia originates in the way a certain group of genes produce abnormalities in the development of the brain. Now these are not gross abnormalities where there are clear deformation of the brain or it doesnâ€™t develop, these are very subtle abnormalities that cause selected neural circuits to form in a way that doesnâ€™t quite make them fully functional and fully viable in the face of all of the different types of activities they have to perform in the course of an individualâ€™s lifetime. And therefore, when theyâ€™re overused or overstressed, they can breakdown. And if they breakdown it causes the symptoms of the illness to develop. So, schizophrenia is believed to develop because of the fact that a certain group of genes affects the way specific neural circuits develop and these happen to be the neural circuits that affect higher thinking processes (how we form beliefs, how we perceive and interpret stimuli) and when these get disturbed, they become dysfunctional, and this produces the symptoms of schizophrenia.
schizophrenia, neurodevelopment, neural circuits, early brain development, schizophrenia symptoms, cause of schizophrenia, neurodevelopmental, chemical changes, biochemistry, Jeffrey, Lieberman, neural mechanisms, brain
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An overview of schizophrenia-related content on Genes to Cognition Online.
814. Dopamine Hypothesis of Schizophrenia
Professor Jeffrey Lieberman discusses the dopamine hypothesis, the predominant neurochemical theory of schizophrenia.
817. Neural Structures and Schizophrenia
Professor David Lewis discusses how the diversity of symptoms in schizophrenia is reflected in the diversity of genetic and neural causes of the disorder.
1183. Serotonin Hypothesis of Schizophrenia
Professor Jeffrey Lieberman discusses the serotonin hypothesis of schizophrenia. Drugs such as LSD and ecstasy block serotonin and produce schizophrenia-like symptoms.
1182. Glutamate Hypothesis of Schizophrenia
Professor Jeffrey Lieberman discusses the glutamate hypothesis of schizophrenia. The drug PCP acts on glutamate receptors, producing schizophrenia-like symptoms.
846. Treatments for Schizophrenia
Many psychiatrists are now prescribing second-generation or 'atypical' antipsychotics.
1291. Schizophrenia - A Review
A review of the causes, symptoms, and treatments of schizophrenia.
1186. Schizophrenia - Early Intervention Targets Grey Matter
Professor Jeffrey Lieberman discusses the importance of early treatment for schizophrenia. Early intervention may delay loss of grey matter, which is symptomatic.
1254. Schizophrenia - Motor Control
Professor David Lewis explains that schizophrenic individuals can have coordination problems, which may relate to impaired neural circuits.
2008. Cognitive disorders are early onset disorders
Doctor Thomas Insel points out that many cognitive disorders have a relatively early onset, and the challenge is to find out the relevant genetic, cellular, and neural correlates.