Growth Cones (2)
Professor David Van Vactor discusses how growth cones read molecular 'signposts,' which help axons find the correct path.
So, the growth cone expresses on its surface a variety of receptors that allow the growth cone to recognize both attractive and repellent cues - stop signs and green lights in the embryonic environment. And these guideposts are there to give the growth cone signals that will define its path. But in order to find the correct path, the growth cone has to respond correctly to those signals and translate the stop and the go signal into forward movement or avoidance.
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Professor David Van Vactor describes how axons grow during neurodevelopment.
Professor David Van Vactor explains how growth cones guide axons during neurodevelopment.
Professor David Van Vactor discusses what happens during neurodevelopment when an axon reaches its final destination.
Professor David Van Vactor describes the role of receptor molecules, which receive signals from outside the cell, passing the signal to the inside.
In this section learn that a signaling pathway begins with the arrival of a chemical signal – such as a hormone or growth factor – at the cell surface.
Signal transduction is cell communication that involves a series of molecular transformations.
In this section learn that the binding of growth factors outside the cell causes receptors ends to intertwine and activate each other, and once active, the modified receptor ends interact with messenger proteins.
This section explains how the protein produced by the K-ras gene is a tumor “activator.”
Professor David Van Vactor provides a simple explanation for why researchers work with model systems (model organisms).
In this section learn that receptors activate each other before binding an adaptor molecule and an exchange factor.