Professor David Van Vactor describes the role of receptor molecules, which receive signals from outside the cell, passing the signal to the inside.
In order for a nerve cell, or any cell, to perceive its environment, it needs a sensory apparatus. And for an individual cell, most of that sensation is derived at the cell surface. So, it expresses on its cell surface proteins that span across the membrane. In the outside world, these proteins can act to receive signals, catching molecules on the outside and then as the molecule passes to the inside of the cell, they can send signals like alarm signals that can tell the cell that a particular molecule is outside.
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- ID: 1069
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1068. The Cytoskeleton
Professor David Van Vactor describes the structure of the cytoskeleton, which acts as a scaffold for the cell.
1066. Growth Cones (2)
Professor David Van Vactor discusses how growth cones read molecular 'signposts,' which help axons find the correct path.
1064. Neurodevelopment - Axon Guidance
Professor David Van Vactor describes how axons grow during neurodevelopment.
1263. What are Model Systems? (2)
Professor David Van Vactor explains that model systems are simple organisms that allow us to study and manipulate gene function and development.
1018. Pathways, At the cell surface
In this section learn that a signaling pathway begins with the arrival of a chemical signal – such as a hormone or growth factor – at the cell surface.
1063. Drosophila as a Model System
Professor David Van Vactor discusses the properties that make the fruit fly (drosophila) a powerful model system.
1019. Pathways, Beneath the membrane
In this section learn that the binding of growth factors outside the cell causes receptors ends to intertwine and activate each other, and once active, the modified receptor ends interact with messenger proteins.
1020. Pathways, A bevy of interactions
In this section learn that receptors activate each other before binding an adaptor molecule and an exchange factor.
1024. Pathways, Releasing the protein
In this section learn that newly made proteins leave the endoplasmic reticulum wrapped in a layer of membrane called a vesicle.
959. Causes, Smoking: K-ras
This section explains how the protein produced by the K-ras gene is a tumor “activator.”