Diagnosis, Pathology: Demarzo clip 3
Professor Angelo De Marzo explains that if you think about the cells as a community of people, normal people would be a group of students in a lecture that are kind of sitting with their shirts and ties nice and orderly.
Angelo De Marzo M.D., Ph.D. is a pathologist at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. His current research focuses on the inflammatory response and its link to prostate cancer. The research may lead to new diagnostic tests for early detection. â€œIf you think about the cells as a community of people, normal people would be a group of students in a lecture that are kind of sitting with their shirts and ties nice and orderly. Theyâ€™re not talking, theyâ€™re not throwing spitballs. They are behaving very nicely and listening to the teacher. A cancer cell would be a population of students that are running around throwing paper airplanes, they are not dressed properly, one might be sitting on another oneâ€™s lap. The cells literally donâ€™t behave in terms of their structure and they might invade their next door neighborâ€™s space. Some of them are too big and some of them are too small so you get what is called polymorphism. So normal, in this analogy, all the kids in the class would all be the same height and weight. In the cancer cell you have a 300 pounder, next to a one pounder, next to you know all different types of people. So that they really socially donâ€™t behave properly as a cell and thatâ€™s really what we are looking for.â€
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- ID: 1008
- Source: DNALC.IC
Professor Angelo De Marzo explains that special dyes are utilized to stain cells and when we look at the stained cells under the microscope we look for changes in the architecture of cells.
Pathology has long been associated with medical development and patient treatment and care. Throughout history pathologists have been trained to observe and recognize abnormalities to diagnose and treat the condition.
Professor Angelo De Marzo explains that every laboratory test in a hospital is run in theory by pathologists, and so they actually are responsible for the output of every lab value.
Professor Nelson explains that GSTP1 doesn't seem to be a gene in prostate cancer at least that's controlling growth, invasion, or metastasis.
Professor Nelson discusses how ecological epidemiology evidence is utilized to determine cancer susceptibility.
Professor Nelson explains that the prostate is actually a male sex accessory gland that contributes about a third of the secretions to the ejaculate for sexual reproduction.
Professor Nelson explains that chlorophyll is a remarkable energy scavenger and that there is some hint that if you consume chlorophyll you can intercept chemical species, that damage proteins, DNA, and RNA.
Professor Nelson explains that there's something about diets of people who get prostate cancer that are a little different from the diets of people that don't.
Meat cooked at high temperatures can produce chemicals that are damaging to cells and DNA.
In order to identify cancer causes and prevention strategies, researchers conduct a cohort of studies where they collect information from large groups of individuals over many years.