Diagnosis, Pathology: Demarzo clip 2

Professor Angelo De Marzo explains that special dyes are utilized to stain cells and when we look at the stained cells under the microscope we look for changes in the architecture of cells.

Angelo De Marzo M.D., Ph.D. is a pathologist at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. His current research focuses on the inflammatory response and its link to prostate cancer. The research may lead to new diagnostic tests for early detection. “Most people don't realize all human tissue is actually transparent until we apply special dyes. So we typically use hemotoxilyn – a very beautiful dye – hemotoxilyn is actually from the bark of a tree. We've been using it for almost 100 years in this country. When we look at that under the microscope we look for a couple things. We usually use the architecture of the cells, how they are arranged together, and also the individual cells themselves. And so a cancer cell, the nucleus of the cell gets very big and it absorbs more dye. It's called hyperchromasia. The nucleus gets abnormal in shape and so in general, pathologists can tell the biological behavior and can guess it by changes in cell shape and structure.”

sidney kimmel comprehensive cancer center, sidney kimmel comprehensive cancer center at johns hopkins, diagnosis pathology, comprehensive cancer center, cell shape, biological behavior, cancer cell, sidney kimmel comprehensive, human tissue, inflammatory response, prostate cancer, diagnostic tests, pathologist, dyes, nucleus, microscope, cells

  • ID: 1007
  • Source: DNALC.IC

Related Content

1006. Diagnosis, Pathology: Demarzo clip 1

Professor Angelo De Marzo explains that every laboratory test in a hospital is run in theory by pathologists, and so they actually are responsible for the output of every lab value.

  • ID: 1006
  • Source: IC

1008. Diagnosis, Pathology: Demarzo clip 3

Professor Angelo De Marzo explains that if you think about the cells as a community of people, normal people would be a group of students in a lecture that are kind of sitting with their shirts and ties nice and orderly.

  • ID: 1008
  • Source: IC

1005. Diagnosis, Pathology

Pathology has long been associated with medical development and patient treatment and care. Throughout history pathologists have been trained to observe and recognize abnormalities to diagnose and treat the condition.

  • ID: 1005
  • Source: IC

983. Causes, Diet: Cause, Nelson

Professor Nelson explains that GSTP1 doesn't seem to be a gene in prostate cancer at least that's controlling growth, invasion, or metastasis.

  • ID: 983
  • Source: IC

979. Causes, Diet: Diet and Cancer, Nelson clip 1

Professor Nelson discusses how ecological epidemiology evidence is utilized to determine cancer susceptibility.

  • ID: 979
  • Source: IC

981. Causes, Diet: Diet and Cancer, Nelson clip 3

Professor Nelson explains that the prostate is actually a male sex accessory gland that contributes about a third of the secretions to the ejaculate for sexual reproduction.

  • ID: 981
  • Source: IC

985. Causes, Diet: Prevention, Nelson

Professor Nelson explains that chlorophyll is a remarkable energy scavenger and that there is some hint that if you consume chlorophyll you can intercept chemical species, that damage proteins, DNA, and RNA.

  • ID: 985
  • Source: IC

982. Causes, Diet: Cause

Meat cooked at high temperatures can produce chemicals that are damaging to cells and DNA.

  • ID: 982
  • Source: IC

980. Causes, Diet: Diet and Cancer, Nelson clip 2

Professor Nelson explains that there's something about diets of people who get prostate cancer that are a little different from the diets of people that don't.

  • ID: 980
  • Source: IC

1025. Causes, Diet

In order to identify cancer causes and prevention strategies, researchers conduct a cohort of studies where they collect information from large groups of individuals over many years.

  • ID: 1025
  • Source: IC