Causes, Diet: Diet and Cancer, Nelson clip 1
Professor Nelson discusses how ecological epidemiology evidence is utilized to determine cancer susceptibility.
William Nelson, M.D., Ph.D. is a researcher at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. HIs research focuses on the molecular causes involved in the development of prostate cancer. This has led to the discoveries that inflammation, diet, and gene "silencing" have roles in prostate cancer development. â€œWell there's one piece of what's called ecological epidemiology evidence that's very strong and dominates many of our thinking, much of our thinking about prostate cancer. And that's a man born in rural Asia, who lives his life in rural Asia, is very unlikely to develop prostate cancer and very unlikely to die from the disease. Now granted they don't screen for prostate cancer there, but mortality rates are reasonably solid that they're very unlikely to die from prostate cancer. And yet when Asian men immigrate to the Western world â€“ so there's been a nice study done where they immigrate to North America â€“ they begin to adopt a risk of prostate cancer that is more consistent with Caucasians and other residents of North America than the area which they left. And they adopt it quickly. If they were here ten years or less, the risk is like they never left Asia, if they're here 25 years or more their prostate cancer mortality risk is about half that of Caucasians. Ethnic Asian men born in this country have a risk that is very close to that of Caucasians. This very strongly suggests that there is something in the environment that is driving the epidemic of prostate cancer in the Western world.â€
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- ID: 979
- Source: DNALC.IC
Professor Nelson explains that GSTP1 doesn't seem to be a gene in prostate cancer at least that's controlling growth, invasion, or metastasis.
Professor Nelson explains that the prostate is actually a male sex accessory gland that contributes about a third of the secretions to the ejaculate for sexual reproduction.
In this section learn how diet can contribute and or be linked to the development of prostate cancer.
In order to identify cancer causes and prevention strategies, researchers conduct a cohort of studies where they collect information from large groups of individuals over many years.
Professor Nelson explains that chlorophyll is a remarkable energy scavenger and that there is some hint that if you consume chlorophyll you can intercept chemical species, that damage proteins, DNA, and RNA.
Professor Nelson explains that there's something about diets of people who get prostate cancer that are a little different from the diets of people that don't.
Meat cooked at high temperatures can produce chemicals that are damaging to cells and DNA.
In addition to enzymes produced by the body, certain components in food can also react with damaging chemicals, and an increased consumption of these foods may lower a person’s risk of cancer development.
Professor Angelo De Marzo explains that special dyes are utilized to stain cells and when we look at the stained cells under the microscope we look for changes in the architecture of cells.
Professor Angelo De Marzo explains that if you think about the cells as a community of people, normal people would be a group of students in a lecture that are kind of sitting with their shirts and ties nice and orderly.