Rat (Rattus norvegicus)
The rat is an ideal research model because scientists have a deep understanding of rat physiological mechanisms. There are numerous rat models that mimic human diseases.
The rat is used extensively as a model organism for studying both normal and disease processes in the human. The rat is an ideal research model because scientists have a deep understanding of rat physiological mechanisms. There are numerous rat models that mimic human diseases. It is relatively easy to generate inbred congenic (nearly identical) and consomic strains. A consomic strain is an inbred strain with one of its chromosomes replaced by the homologous chromosome of another inbred strain via a series of marker-assisted backcrosses.
Rat, rattus norvegicus, model, systems, organisms, homology
- ID: 1717
- Source: DNALC.G2C
Model organisms share with humans many key biochemical and physiological functions that have been conserved (maintained) by evolution.
Yeast was the first eukaryote organism to have its entire genome sequenced. It has remained at the forefront of genetics research because it is quick and easy to grow.
There are only 50 human genes that have no homolog in chimps. Differences between the two species are, therefore, due more to changes in gene regulation.
Some of the plants, animals, and microorganisms used by researchers as "model" biological systems.
Each model organism has its own advantages and disadvantages. Choosing an appropriate model depends on the question being asked. Many laboratories find it useful to perform parallel experiments in two or more model systems to understand different aspects
Model organisms such as yeast, bacteria, the mouse and the fruit fly are used by researchers to study biological systems. The genomes of these organisms have been mapped and sequenced.
Professor David Van Vactor provides a simple explanation for why researchers work with model systems (model organisms).
Mice are small, easy to keep, and complete a generation in only ten weeks. They are also rather closely related to human beings.
Professor David Van Vactor explains that model systems are simple organisms that allow us to study and manipulate gene function and development.