Flow of Information from DNA to RNA to Protein

Nobel Laureate Dr. Rich Roberts describes the flow of information from DNA to RNA to protein.

The central dogma basically says that the information in an organism, that decides and organism, that describes everything that it can do is encoded in the DNA. And that DNA is then copied into something called RNA, which is very similar, it has exactly the same sequence as DNA, but it's easily changed. It's much easier to work with, it can be degraded whereas DNA is rather solid. And then from the information in the RNA, you can then make protein by reading the sequence of bases in the RNA three at a time and three code for one amino acid. So if you want to make a hundred amino acid protein, you need a piece of RNA that is 300 bases long. But in a bacterium, you can make the RNA and it looks exactly like the DNA and it can then go straight into the ribosome in order to make the protein. But in eukaryotes, when you make the first piece of RNA, you can't read it three at a time because it's got all of these extra segments in it that are separating out the coding region. And so you have to do this cutting and splicing process in order to then make something that looks like a bacterial messenger RNA.

Spinal muscular atrophy, SMA, RNA, mRNA, splicing, gene, genetic, DNA, antisense, motor neuron, splice, Central dogma, transcription, translation, intron, exon, encode, read, protein, pre mRNA, trait, function, prokaryote, eukaryote

Related Content

16941. 2D Animation of Alternative RNA Splicing

An animation shows alternate splicing of the SMN2 gene.

  • ID: 16941
  • Source: DNALC.SMA

16939. RNA Splicing

A step-by-step 2D animation shows the details of RNA splicing.

  • ID: 16939
  • Source: DNALC.SMA

16938. 3D Animation of RNA Splicing

An animation of the crucial RNA editing step called splicing.

  • ID: 16938
  • Source: DNALC.SMA

16935. The Connection Between SMA and RNA Splicing

Dr. Krainer explains the connection between SMA and RNA splicing.

  • ID: 16935
  • Source: DNALC.SMA

16950. 2D Animation of Antisense Oligonucleotide Therapy for SMA

An animation shows how antisense oligonucleotide therapy for SMA utilizes RNA splicing.

  • ID: 16950
  • Source: DNALC.SMA

16933. 3D Animation of DNA to RNA to Protein

An animation shows how the DNA genetic "code" is made into protein.

  • ID: 16933
  • Source: DNALC.SMA

16937. An Explanation of RNA Splicing

Dr. Sharp explains the process of RNA splicing.

  • ID: 16937
  • Source: DNALC.SMA

16949. Antisense Oligonucletotide Therapy for SMA

Dr. Krainer explains the science behind antisense therapy for SMA.

  • ID: 16949
  • Source: DNALC.SMA

16936. An Introduction to RNA Splicing

Dr. Roberts describes RNA splicing.

  • ID: 16936
  • Source: DNALC.SMA

16940. Alternative RNA Splicing

Drs. Sharp and Krainer explain how genes can be alternatively spliced.

  • ID: 16940
  • Source: DNALC.SMA