An Explanation of RNA Splicing
Nobel Laureate Dr. Phil Sharp explains the process of RNA splicing.
Oh, well, the discovery I made in the '77 was of the split gene nature of the genes in human cells. What I mean by that is that if you look at the information within a gene and in terms of the DNA sequence, it is interrupted by non-informational DNA or nonsense DNA. The nonsense DNA is called introns, the sense DNA is called exons. So you get exon, intron, exon, intron type patterns in genes. They have to remove the nonsense for the gene work, the cell does, and it does that by splicing out the nonsense and putting the sense segments together. The cell in essence edits the structure of a gene to make the information that is then used by the cell as a functional unit for cellular activities. So we discovered that in 1977 in Cold Spring Harbor in parallel and independently made a similar discovery.
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- ID: 16937
- Source: DNALC.SMA
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An animation shows alternate splicing of the SMN2 gene.
A step-by-step 2D animation shows the details of RNA splicing.
Dr. Krainer explains the connection between SMA and RNA splicing.
An animation of the crucial RNA editing step called splicing.
An animation shows how antisense oligonucleotide therapy for SMA utilizes RNA splicing.
Drs. Sharp and Krainer explain how genes can be alternatively spliced.
Dr. Krainer explains the science behind antisense therapy for SMA.
Dr. Roberts describes RNA splicing.
Drs. Sharp and Sumner describe how RNA splicing can be used as a therapy for SMA.
Dr. Sumner explains how SMA is related to changes in the SMN1 and SMN2 genes.