The Connection Between SMA and RNA Splicing
Researcher Dr. Adrian Krainer explains the connection between SMA and RNA splicing.
So the connection between splicing and SMA is actually twofold. You know, one has to do with the function of the SMN protein itself or one of its functions, which is to assemble components that are critical for splicing in general. And the second connection has to do with splicing of the SMN2 gene itself. Because it is alternatively spliced in a way that gives a reduced amount of functional SMN protein, if it's possible to target that gene and change its splicing to give more full length SMN protein that would make it a more functional gene.
Spinal muscular atrophy, SMA, RNA, mRNA, splicing, gene, genetic, DNA, antisense, motor neuron, splice, Transcription, intron, exon, pre mRNA, splicing, spliceosome, function, alternative splicing, binding site, exon 7
- ID: 16935
- Source: DNALC.SMA
- Download: MPEG 4 Video
An animation shows alternate splicing of the SMN2 gene.
A step-by-step 2D animation shows the details of RNA splicing.
Dr. Sharp explains the process of RNA splicing.
An animation of the crucial RNA editing step called splicing.
An animation shows how antisense oligonucleotide therapy for SMA utilizes RNA splicing.
Drs. Sharp and Krainer explain how genes can be alternatively spliced.
Dr. Krainer explains the science behind antisense therapy for SMA.
Dr. Roberts describes RNA splicing.
Drs. Sharp and Sumner describe how RNA splicing can be used as a therapy for SMA.
Dr. Sumner explains how SMA is related to changes in the SMN1 and SMN2 genes.