Video 33: Walter Gilbert, clip 6
Walter Gilbert is the Carl M. Loeb University Professor at Harvard University. In 1980, he won a Nobel Prize in Chemistry for his work on DNA sequencing.
nobel prize in chemistry, jacob and monod, walter gilbert, dna sequencing, harvard university, loeb, proteins,
- ID: 16699
- Source: DNALC.DNAFTB
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How Jacob and Monod showed the existence of the inhibitor (what Gilbert calls the repressor).
Jacob and Monod never identified the inhibitor, but Gilbert found it.
Before Jacob and Monod, people thought the amount of protein in a cell was constant and proteins turned themselves off.
Jacob and Monod discovered that genes control the amount of protein in a cell.
To explain their data, Jacob and Monod had to hypothesize the existence of mRNA.
Where did the idea of negative control come from?
Frederick Sanger received two Nobel prizes (in the same category), for his work on protein sequencing and DNA sequencing.
Francois Jacob and Jaçques Monod figured out how bacteria controlled the production of an enzyme called beta-galactosidase. This system of feedback and negative regulation became the lac operon and was the first model for the control of protein productio
Walter Gilbert's group tried to isolate the human insulin DNA sequence using the rat insulin DNA sequence.
François Jacob and Jacques Monod were the first to discover how genes were turned on and off.