Walter Gilbert talks about his group's early success with isolating the rat insulin gene and making recombinant rat insulin.
Walter Gilbert talks about close but no cigar.
The recombinant DNA moratorium meant Gilbert had to go to England's Porton Down facility to try and isolate human insulin. He only had one chance ...
David Goeddel talks about how another group was trying to make insulin.
Walter Gilbert talks about the reasons for making insulin with recombinant DNA.
In the late 1970s, there was a moratorium on recombinant DNA work. Gilbert had to go to England's Porton Down facility to try and isolate human insulin.
Walter Gilbert talks about his feelings regarding the insulin project and science in general.
How Jacob and Monod showed the existence of the inhibitor (what Gilbert calls the repressor).
Jacob and Monod never identified the inhibitor, but Gilbert found it.
Before Jacob and Monod, people thought the amount of protein in a cell was constant and proteins turned themselves off.