Alfred Henry Sturtevant (1891-1970)
Alfred Henry Sturtevant was born in Jacksonville, Illinois. Sturtevant was always interested in inheritance and genetics. One of Sturtevant's earliest publications was a pedigree analysis of horses owned by his father. In 1909, while an undergraduate at Columbia University, Sturtevant attended a lecture given by Thomas Hunt Morgan. It was one of the few undergraduate classes that Morgan ever taught. Morgan's passion for science and discovery interested Sturtevant so much that he approached Morgan about working for him. Sturtevant became one of Morgan's first students in the "Fly room" to work on Drosophila melanogaster.
For his Ph.D. thesis, Sturtevant published the world's first genetic map. The idea of gene linkage came to him in a flash one night. He and the other members of Morgan's lab had been discussing a paper on the coat color of rabbits. Sturtevant realized that genes were linked in a series, and data as to how these genes were linked could be deduced by building the "right" Drosophila mutant. Sturtevant stayed up most of one night working out the details of linkage analysis instead of doing his undergraduate homework.
In 1928, Sturtevant, along with Thomas Hunt Morgan and Calvin Bridges, moved to the California Institute of Technology. Sturtevant was a Professor of Biology at Cal Tech until 1951.
Alfred Sturtevant was a student of Thomas Hunt Morgan. Sturtevant provided proof of genetic linkage. Bridges advanced the theory of chromosomal non-disjunction, and did a lot of work on chromosomal banding patterns.
alfred henry sturtevant, thomas hunt morgan, gene linkage, calvin bridges, genetic map,genetic linkage, linkage analysis, pedigree analysis, inheritance, biology, fly room, drosophila melanogaster,mutant
- ID: 16297
- Source: DNALC.DNAFTB
Thomas Hunt Morgan was one of the first true geneticists.
Calvin Bridges was a student of Thomas Hunt Morgan. Bridges advanced the theory of chromosomal non-disjunction, and did a lot of work on chromosomal banding patterns.
New York high school students set out to find Thomas Hunt Morgan's "Fly Room" at Columbia University, where seminal genetics research took place in the early 20th century.
DNAFTB Problem 11: Determine gene linkage in fruit flies.
William Bateson brought Mendel's laws to the attention of English scientists. Bateson and Reginald Punnett co-discovered "coupling," or gene linkage.
The fruit fly is easy to maintain, has large numbers of offspring, and grows quickly. The fruit fly shares with humans a number of so-called “master,” or homeotic, genes.
Biology staff at Caltech, 1930.
Thomas Hunt Morgan in the Fly Room at Columbia (2), 1917.
Linkage groups on chromosomes gave clues to where genes are located.
DNAFTB Animation 11: Alfred Sturtevant describes gene mapping.