Gene hierarchy, John Sulston
Interviewee, John Sulston. John Sulston talks about gene hierarchy.
I think it's very important to bear in mind too that we don't know, it doesn't make any difference to our view whether it's a hundred thousand or thirty thousand, what our view should be, because we don't know how the genes operate and in particular we don't know how they fit together in hierarchies. The thing that, that counts is not the number of genes, but the number of different cascades you can make from them, because what happens is that in the control of human development one gene turns on other genes, turns on other genes, turns on other genes, there's a whole sort of management hierarchy.
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Nobel Laureate John Sulston, a key figure in the UK sequencing effort, talks about breaking DNA apart so that the sequence can be reassembled.
Hierarchy of levels of chromatin condensation.
Nobel Laureate John Sulston speaks about the relationships between organisms, and why one organism can be a good model for another.
Commentators on the genome sequence (Human Genome Project). Top: William Clinton, Ewan Birney, John Sulston. Bottom: Jim Watson, Craig Venter.
Model organisms researchers: (clockwise from top left) David Botstein, Mario Capecchi, John Sulston, Ewan Birney, and Sydney Brenner.
John Sulston talks about response of the media.
Affymetrix, the makers of GeneChip arrays.
Nobel Laureate John Sulston reflects on the Human Genome Project from an evolutionary perspective.
John Sulston, a key figure in the public genome project, speaks about the difficulties posed by missing a step in the sequencing process.
Stephen Fodor continues his discussion of the experiments that laid the groundwork for GeneChip technology.