Mice used as model organisms
Gene targeting techniques are used by scientists to simulate human genetic disorders in model organisms. Many scientists believe that gene targeting will lead the way to new methods for correcting genetic defects. Pioneered by Mario Capecchi, gene targeting is a process in which scientists use embryonic stem (ES) cells to simulate genetic disorders in mice, study their development, and test new therapies. Many believe that gene targeting will lead the way to new methods for directly correcting genetic defects.
human genetic disorders,mario capecchi,model organisms,genetic defects,genetic disorders,embryonic stem,mice,scientists,cells
- ID: 15707
- Source: DNALC.DNAi
Mario Capecchi at work in his laboratory.
image of a mouse.
Mario Capecchi talks about the advantages of working with mice to study genetic disorders.
Mario Capecchi, Distinguished Professor, Eccles Institute of Human Genetics.
Mice are small, easy to keep, and complete a generation in only ten weeks. They are also rather closely related to human beings.
Model organisms share with humans many key biochemical and physiological functions that have been conserved (maintained) by evolution.
When model organisms cannot provide the information needed to answer a particular research question, biologists can turn to cultured human cells.
Doctor Thomas Insel makes the case for model animals with the power to see how candidate genes for human disorders could affect other systems.
Mario Capecchi talks about manipulating embryonic stem (ES) cells to make specific mutations in mouse embryos.
Mario Capecchi describes proteomics; the large-scale study of protein structure and function. Brian Sauer explains gene knock outs.