Imagining transcription in the cell, Sydney Brenner
Interviewee: Sydney Brenner. Sydney Brenner describes what messenger RNA production would look like. (DNAi Location: Code > Copying the code > Players > Sydney Brenner > The snake pit)
Be like snakes. You see, let me tell you what it is. If you look at a bacterium and you say you've got these ribosomes and then you see these pictures in the books of messenger RNA and the ribosomes running on messenger RNA, those are all wrong, those pictures are wrong. If you see these books you see a little DNA circle drawn in a bacterium, that's also wrong. The DNA is folded one thousand times. The length of DNA in a bacterium is about a millimeter, the bacterium is one micrometer, one micron long. So the DNA is rolled up and folded many, many times inside this. And of course when the messenger comes out, comes off the DNA, what you have to imagine is it threading itself through these almost stationary ribosomes, because they're big and they don't diffuse like a bunch of snakes. So if you really wanted to imagine the reality, it would be these snake-like molecules, writhing their way through this lattice of ribosomes in a bacterium.
sydney brenner,messenger rna,snake pit,ribosomes,dnai,location code,bacterium,ribosome,interviewee,micrometer,millimeter,lattice,snakes,micron,dna,molecules,bacteria,transcription
- ID: 15287
- Source: DNALC.DNAi
- Download: MPEG 4 Video Theora Video
Related Content
15285. RNA transcription/translation, Sydney Brenner
In this first of a two-part clip, Sydney Brenner describes the information transfer problem from DNA to the protein-making machinery.
15286. Viral RNA can reprogram the ribosomes, Sydney Brenner
In this second of a two-part clip, Sydney Brenner describes the experiment they did to prove the existence and function of RNA.
15330. Messenger RNA, Matthew Meselson
Matt Meselson also had a hand in Sydney Brenner's RNA experiment. He talks about the experiment and how they waited for James Watson's group to finished their RNA work before publishing.
15274. The production of messenger RNA, François Jacob
François Jacob, Sydney Brenner and Matt Meselson worked on the role of mRNA. An on/off switch involving mRNA seemed a logical control point for protein production.
15280. After the discovery of the double helix structure, Sydney Brenner
Sydney Brenner talks about James Watson's work on RNA.
15510. Transcription: DNA codes for messenger RNA (mRNA), 3D animation with basic narration
Transcription factors bind to DNA, RNA polymerase begins transcribing messanger RNA (mRNA) molecule from DNA.
15501. Translation: RNA to protein, 3D animation with basic narration
3D animation of translation: RNA to protein.
15480. Transcription: DNA to RNA, 3D animation with sound effects only
Transcription factors bind to DNA, RNA polymerase begins transcribing messanger RNA (mRNA) molecule from DNA.
16471. Animation 21: RNA is an intermediary between DNA and protein.
Francis Crick describes RNA and its role and Paul Zamecnick explains protein synthesis.
16933. 3D Animation of DNA to RNA to Protein
An animation shows how the DNA genetic "code" is made into protein.