Viral RNA can reprogram the ribosomes, Sydney Brenner
Interviewee: Sydney Brenner. In this second of a two-part clip, Sydney Brenner describes the experiment they did to prove the existence and function of RNA. (DNAi Location: Code > Copying the code > Players > Sydney Brenner > On the beach - Part II)
So what you have to imagine then, if you have a bacterium where all of this is going in, we now inject a new DNA, which comes out of this virus, which carries the messages for the viral proteins and then we knew there was this small RNA, this small amount of RNA, which was a copy of this chemically, I'd satisfied the base composition. And so what we had to prove is that this new RNA goes into pre-existing ribosomes, and then it reprograms them, so it stops playing rock and roll and now starts to play a little minuet of the phage, so that you can get the phage proteins made. And that was the experiment we set out to do.
sydney brenner,viral rna,viral proteins,base composition,protein production,function of rna,ribosomes,dnai,location code,phage,interviewee,minuet,bacterium,rock and roll,transcription,dna,existence,virus,translation
- ID: 15286
- Source: DNALC.DNAi
Sydney Brenner describes what messenger RNA production would look like.
In this first of a two-part clip, Sydney Brenner describes the information transfer problem from DNA to the protein-making machinery.
François Jacob, Sydney Brenner and Matt Meselson worked on the role of mRNA. An on/off switch involving mRNA seemed a logical control point for protein production.
Matt Meselson also had a hand in Sydney Brenner's RNA experiment. He talks about the experiment and how they waited for James Watson's group to finished their RNA work before publishing.
Explore the reverse transcriptase mechanism.
Sydney Brenner showed that mRNA was the unstable intermediate that carried the message from DNA to the ribosomes.
Sydney Brenner talks about James Watson's work on RNA.
RNA is an intermediary between DNA and protein.
Francis Crick describes RNA and its role and Paul Zamecnick explains protein synthesis.
Dr. Roberts describes the flow of information from DNA to RNA to protein.