Genentech's approach to making insulin, David Goeddel
Interviewee: David Goeddel. David Goeddel was one of the first scientists Herb Boyer hired for the insulin project. Here, David Goeddel talks about Genentech's general strategy for synthesizing insulin. (DNAi Location: Manipulation > Production > Players > Herbert Boyer > The steps to insulin)
The Genentech approach to the insulin project was to ultimately create a gene that could be recognized by bacteria and produce human insulin. We had three major steps to do that is how we divided the program. The first step was the chemical synthesis of the gene itself, and assembling it; the second step was to take the chemically synthesized gene and to clone it and by that means insert it into bacteria in a way that the gene can be replicated in producing unlimited quantities. And the third step is the production or manufacturing step, which is really coaxing the bacteria into recognizing this sequence and actually producing the final product, the human insulin.
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David Goeddel talks about what it was like to work at Genetech during its early days.
David Goeddel talks about how another group was trying to make insulin.
David Goeddel talks about the strategy Genentech used in making synthetic insulin.
Genentech, the first biotechnology company, established in 1976.
In 1980, Genentech became the first publicly traded biotech company. David Goeddel talks about his investment.
Synthesizing human insulin using recombinant DNA, 3D animation with no audio
David Goeddel talks about the other groups working on the insulin problem.
Walter Gilbert talks about his group's early success with isolating the rat insulin gene and making recombinant rat insulin.
Tour of Genentech by David Ebersman
David Goeddel had a problem: how to synthesize human insulin? His relentless energy and tenacity pushed the insulin project to success. Goeddel relaxes by going mountain-climbing.