Presenilin 2 Gene

Presenilin 1 (PS1 or PSEN1) and presenilin 2 (PS2 or PSEN2) are proteins that span the cell membrane and are primarily expressed in neurons.

Presenilin 1 (PS1 or PSEN1) and presenilin 2 (PS2 or PSEN2) are proteins that span the cell membrane and are primarily expressed in neurons. Presenilin 1 and Presenilin 2 determine gamma-secretase activity, which is responsible for cleaving the amyloid precursor protein (APP). In turn, APP cleavage can produce amyloid-beta, which is the primary component of plaques in the brains of Alzheimer’s disease patients. It follows, that interactions between presenilins and APP are critical to the cause/prevention of Alzheimer’s disease, and presenilins have been consistently shown to associate with the disorder (see, for example a review by Selkoe and Wolfe, 2007).

alzheimer's, genes, presenilin, ps2, psen2, cleavage, plaques, proteins, gamma secretase, cell membrane

  • ID: 1450
  • Source: DNALC.G2C

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  • ID: 1449
  • Source: G2C

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  • ID: 1447
  • Source: G2C

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  • ID: 2135
  • Source: G2C

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  • ID: 1448
  • Source: G2C

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  • ID: 799
  • Source: G2C

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  • ID: 2137
  • Source: G2C

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  • ID: 796
  • Source: G2C

1452. Tau Gene (MAPT)

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  • ID: 1452
  • Source: G2C

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  • ID: 794
  • Source: G2C

2028. Senile plaques and Alzheimer's disease

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  • ID: 2028
  • Source: G2C