Presenilin 1 Gene

Presenilin 1 (PS1 or PSEN1) and presenilin 2 (PS2 or PSEN2) are proteins that span the cell membrane and are primarily expressed in neurons.

Presenilin 1 (PS1 or PSEN1) and presenilin 2 (PS2 or PSEN2) are proteins that span the cell membrane and are primarily expressed in neurons. Presenilin 1 and Presenilin 2 determine gamma-secretase activity, which is responsible for cleaving the amyloid precursor protein (APP). In turn, APP cleavage can produce amyloid-beta, which is the primary component of plaques in the brains of Alzheimer’s disease patients. It follows, that interactions between presenilins and APP are critical to the cause/prevention of Alzheimer’s disease, and presenilins have been consistently shown to associate with the disorder (see, for example a review by Selkoe and Wolfe, 2007).

alzheimer, gene, presenilin, ps1, psen1, cell membrane, cleavage, plaques, proteins, gamma secretase

  • ID: 1449
  • Source: DNALC.G2C

Related Content

1450. Presenilin 2 Gene

Presenilin 1 (PS1 or PSEN1) and presenilin 2 (PS2 or PSEN2) are proteins that span the cell membrane and are primarily expressed in neurons.

  • ID: 1449
  • Type:
  • Source: G2C

1447. Alzheimer's Disease Candidate Genes

Genes that can cause neurofibrillary tangles and amyloid plaques are strongly associated with Alzheimer's disease.

  • ID: 1449
  • Type:
  • Source: G2C

2135. APP - amyloid clearance and production

Professor Dennis Selkoe compares the amyloid precursor (or parent) protein to a Bic pen. The clasp part seems to be the bad guy, and is part of a network involving presenilin and ApoE4.

  • ID: 1449
  • Type:
  • Source: G2C

1448. APP Gene

Amyloid precursor protein (APP) is expressed in the synapses of neurons and is thought to be responsible for forming and repairing synapses.

  • ID: 1449
  • Type:
  • Source: G2C

799. Beta-amyloid Plaques

Alzheimer's disease is characterized by abnormal plaques and tangles in the brains of patients.

  • ID: 1449
  • Type:
  • Source: G2C

2137. Amyloid plaques - rarely found in childhood

Professor Dennis Selkoe discusses the age at which plaque-forming a-beta can begin to build up. Children with Down syndrome may have these plaques, otherwise childhood instances are rare.

  • ID: 1449
  • Type:
  • Source: G2C

796. New Treatments for Alzheimer's Disease

Researchers reported progress on several potential drug therapies for people with Alzheimer's disease.

  • ID: 1449
  • Type:
  • Source: G2C

1452. Tau Gene (MAPT)

Neurofibrillary tangles are bundles of tau proteins, which mark the tau gene (MAPT) as a strong candidate for Alzheimer’s disease.

  • ID: 1449
  • Type:
  • Source: G2C

794. Background to Alzheimer's Disease

Alzheimer’s disease is a progressive brain disorder that causes a gradual and irreversible loss of higher brain functions, including memory, language skills, and perception of time and space,

  • ID: 1449
  • Type:
  • Source: G2C

2028. Senile plaques and Alzheimer's disease

Professor Kenneth Kosik describes senile plaques, an extracellular collection of a-beta protein. It is one of the hallmarks of Alzheimer's disease.

  • ID: 1449
  • Type:
  • Source: G2C