Professor David Porteous explains that a translocation is the relocation of part of one chromosome to a another chromosome.
Translocation, if we break down the word, means "trans" - across, and "location" - place. So what that means for a human geneticist or a cytogeneticist, is that there has been a breakage and rejoining of two bits of the human genome in the form of chromosomes. So, to give you a specific example, if we have a translocation between human chromosomes 1 and 11, that means there's been a break on human chromosome number 1 and a break on human chromosome number 11; and a bit of chromosome 1 has transferred to the chromosome 11, and the reciprocal event a bit of chromosome 11 is transferred to the chromosome 1. That, in essence, is what we mean by a translocation.
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Professor David Porteous explains that breakpoints in the genome are locations on a chromosome where DNA might get deleted, inverted, or swapped around.
Professor David Porteous discusses how his group discovered the DISC1 gene, which is a balanced translocation between chromosomes 1 and 11.
Professor David Porteous comments on the fact that aspects of media can be inappropriate and damaging in reporting on genetics research.
Professor David Porteous describes how his group was first alerted to the DISC1 gene, which was found in a family with a pedigree of schizophrenia and psychoses.
David Botstein is a pioneer of modern genetics.
Professor David Porteous discusses genes for schizophrenia and points out that susceptibility likely aligns to a combination of genetic variants.
David Botstein (sitting with Pat Brown) talks about how innovations in genomics might lead to personalized medicine.
Professor David Porteous describes how his group is trying to uncover the function of the DISC1 gene.
Evolutionary geneticist Michael Hammer talks about the limitations of Y-chromosome research and the histories of different genes.