Studying Excitatory and Inhibitory Networks
Professor William Kristan describes difficulties in building excitatory and inhibitory networks, which can either run out of control or remain inactive.
So, excitatory and inhibitory networks, most networks are a combination of the two, but in fact a lot of times they are predominantly one or the other. So excitatory just means that all the cells, all the neurons in a network are exciting each another, exciting the connections. The synapses they make on one another cause more activity, so they cause the cells to be more active and inhibitory would turn them off. Surprisingly, you would imagine one of the problems with excitatory networks is that they tend to run away, one will excite another, which will excite another, and they will tend to explode. Inhibitory networks tend to turn themselves off, so they have to have a constant level of excitation or inherent activity. So, the problems that one gets into in either building these kinds of networks or in studying them, is a bit different because in one case they tend to get out of hand, and in another case they tend to go nowhere.
synapse, excitation, inhibition, excitatory, inhibitory, excite, inhibit, neuron, cell, william, kristan,
Professor William Kristan explains that synaptic networks are a connection of cells, all of which perform the same function (e.g. inhibition, modulation).
Gamma-aminobutyric acid (GABA) is a very common neurotransmitter in the Central Nervous System, whose primary function is to inhibit the transmission of a signal through a neuron.
Doctor Josh Dubnau explains that the genes active in different neurons can make them excitatory (e.g. glutamate) or inhibitory (e.g. GABA). These neurotransmitters are critical to learning.
An overview of language-related content on Genes to Cognition Online.
Professor William Kristan explains that synaptic networks differ from neuronal networks in that they are relevant to HOW cells interact.
Unlike other organs, the brain has evolved to adapt to the environment. This unique ability is driven by communication between many billions of neurons.
Professor Trevor Robbins describes the GABA (or GABAergic) system, whose main function in the brain is inhibition.
Professor Seth Grant explains that NMDA is an amino acid derivative very similar to glutamate - the brain's primary excitatory neurotransmitter.
The idea that drug addiction is a result of 'learning gone wild' was bolstered by several reports.
Professor Bruce McEwen introduces BDNF, a class of neurotrophic molecules released by excitatory neurotransmission and associated with key process and disorders.